STRUCTURE OF A NEW SCHIFF BASE COBALT(III) COMPLEX WITH ANTIBACTERIAL ACTIVITY
A new Schiff base cobalt(III) complex with the formula [CoL1L2(N3)]?NO3 (L1 is 2-[1-(2-phenylaminoethylimino)ethyl]phenolate, L2 is N-phenylethane-1,2-diamine) is prepared and characterized by physicochemical methods and single crystal X-ray determination. The complex crystallizes in the triclinic system space group P-1, with a = 8.504(2) ?, b = 14.973(3) ?, c = 20.676(4) ?, a = 100.021(3)°, b = 90.005(3)°, g = 103.084(2)°, V = 2523.0(9) ?3, Z = 4, R1 = 0.0732, and wR2 = 0.1182. Single crystal X-ray diffraction analysis reveals that the complex contains two mononuclear [CoL1L2(N3)]+ cations and two nitrate anions. The Co atom is six-coordinated in an octahedral geometry. The ligands and the cobalt(III) complex are screened in vitro for their antibacterial activity against Bacillus subtillis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aereuguinosa.
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Single crystal X-ray diffraction analysis reveals that the complex contains two mononuclear [CoL1L2(N3)]+ cations and two nitrate anions. <...> The Co atom is six-coordinated in an octahedral geometry. <...> The ligands and the cobalt(III) complex are screened in vitro for their antibacterial activity against Bacillus subtillis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aereuguinosa. <...> This work deals with the synthesis and characterization of a new cobalt(III) complex of [CoL1L2(N3)]ŒNO3, where L1 is 2-[1-(2-phenylaminoethylimino)ethyl]phenolate and L2 is N-phenylethane-1,2-diamine. <...> The antibacterial activity of the ligands and the cobalt(III) complex was studied against the bacterial species Bacillus subtillis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aereuguinosa. <...> EXPERIMENTAL Materials and methods. 2-Acetylphenol and N-phenylethane-1,2-diamine with analytical grade were available from Alfa Aesar Company. obalt nitrate and other chemicals with analytical grade were purchased from Beijing Chemical Reagent Company and were used without further purification. <...> The hydrogen atoms attached to the secondary amines were located from a difference Fourier map and refined isotropically, with N—H distances restrained to 0.90(1) Е. <...> The antibacterial activities of the compounds were tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus respectively. <...> The concentration of each solution was 1.0ė10–3 M. RESULTS AND DISCUSSION The Schiff base HL1 was synthesized by the condensation of equimolar quantities of 2-acetylphenol with N-phenylethane-1,2-diamine in methanol with quantitative yield. <...> We have tried to use the Schiff base and sodium azide to react with cobalt nitrate in various solvents such as methanol, ethanol, chloroform, and acetonitrile, but no single crystals of the final complex were obtained. <...> Accidently, the starting materials 2-acetylphenol with a two-equivalent molar ratio of N-phenylethane-1,2-diamine reacted with cobalt nitrate in methanol in the presence of sodium azide, yielding the red block-shaped single crystals of the cobalt(III) complex with high quality and satisfactory yield. <...> The IR spectra of the complex show middle N—H bands at 3127 cm–1 and 3163 cm–1, indicating the existence of two different types of amino H atoms. <...> The bands are shifted towards lower frequencies when compared to those observed in the spectra of the HL1 and L2 ligands, indicating the coordination of amino nitrogen to the Co <...>
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