Epidemiological and nutrition transition
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Huge effort is now invested in study of various candidate genes and potential specifi c polymorphisms
selected from functional genomic data-bases and implementing bioinformatics tools. <...> Numerous whole genome
linkage and currently association studies identifying hundreds of new suggestive polymorphisms and dozens
of new genes are also waiting for approval from the same sources of functional genomics. <...> These results if
confi rmed could be of considerable basic scientifi c and clinical signifi cance, in particular for the personalized
medicine. <...> The present talk will illustrate this status of affairs in our research, focused on bone strength/fragility
and sarcopenia related phenotypes. <...> In particular, this presentation will show the main results of our research
implementing modern “omics” methods including whole genome and metabolome studies to identify specifi c
genetic factors and endogenous molecules associated with muscle mass and sarcopenia related phenotypes
in general population. <...> I will present some selected results of the GWAS and functional genomics analysis of
the muscle mass variation obtained in largest up-to-date international consortium. <...> Key words: muscle mass, BMD, GWAS, candidate genes, association analysis
Contact information: Livshits Gregory, e-mail: gregl@post.tau.ac.il. <...> EPIDEMIOLOGICAL AND NUTRITION TRANSITION: THE DOUBLE BURDEN
OF MALNUTRITION
Mascie-Taylor Christopher Guy Nicholas
Department of Archaeology and Anthropology, University of Cambridge, UK
The theory of the epidemiological transition focuses on the complex changes in patterns of nutrition,
health and disease and on the interactions between these patterns and their demographical, economical and
sociological determinants and consequences. <...> The theory was fi rst put forward by Abdel R. Omran based on
his analyses and comparisons of mortality patterns. <...> The Epidemiological Transition is obviously linked to demographic and nutrition transitions. <...> As far as
nutrition is concerned changes in dietary and physical activity patterns are partly responsible for the secular
trend in average stature and alterations in body composition. <...> Many countries are suffering from both undernutrition as well as overnutrition (i.e. the double burden of
malnutrition).
tions. <...> This paper reviews these concepts and considers how aid programmes can impact on these transiKey
words: Epidemiological Transition, demography, malnutrition, undernutrition, overnutrition
Contact information: Mascie-Taylor Christopher Guy Nicholas, e-mail <...>
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