Apolipoprotein E and ACE genotypes modulate allostatic load

антропогенетика apolipoprotein E аполипопротеин Е АПФ генотипы ACE genotypes allostatic load non-communicable diseases неинфекционные заболевания mortality генотипы genotypes diseases заболевания болезни смертность ангиотензинпревращающие ферменты genes гены life span продолжительность жизни генетика человека stressors American Samoans

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Section MOLECULAR ANTHROPOLOGY – NEW ADVANCES 117 APOLIPOPROTEIN E AND ACE GENOTYPES MODULATE ALLOSTATIC LOAD Crews Douglas E., Donley Gwendolyn Department of Anthropology and School of Public Health, Ohio State University, Columbus, USA Over a life span, both failed and successful responses to stressors promote physiological dysfunction, leading eventually to an allostatic load (AL). <...> Additionally, age, sex, occupation, sociocultural factors and self-perceptions affect physiological responses and structure predispositions to non-communicable diseases and mortality. <...> Measurement of AL assesses physiological dysfunction secondary to lifelong responses to stressors. <...> We examined associations of AL with apolipoprotein (Apo) E and H, ACE, and ANP genotypes in 284 American Samoans. <...> AL was measured using seven secondary mediators of allostasis, along with aspects of body habitus and glucose metabolism. <...> AL differed little by Apo H or ANP genotypes. <...> However, signifi cant differences in Al were observed across Apo E and ACE genotypes. <...> Participants with the Apo E 3*2 genotype showed the lowest AL compared to 3*3 or 2*2 genotypes. <...> AL associates signifi cantly with morbidity and mortality across multiple samples, our results suggest these relationships may depend in part on underlying genotypes. <...> Key words: American Samoans, life span, stress, stressors, physiological dysfunction Contact information: Crews Douglas E., e-mail: crews.8@osu.edu. <...> GENETIC DIVERSITY OF INDEGENOUS POPULATIONS OF TUVA REPUBLIC ON SNP – HAPLOGROUPS OF Y-CHROMOSOME Damba Larissa1,2 , Skhalyakho Roza2,3 Dibirova Khadizhat2,3 Republic, Kyzyl, Russia 2 , Bogunovа Anna4 , Yusupov Uldash5 , Bogunov Yuriy2,3 , Zhabagin Maxat6 , Agdzhoyan Anastasiya3 , Balanovsky Oleg3,2 1Research Institute of Medical and Social Problems and Control of the Healthcare, Department of the Tyva Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia 3Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia 4Amur State University of Humanities and Pedagogy, Komsomolsk-on-Amur, Russia 5Institute for Humanities Research of Republic of Bashkortostan, Ufa, Russia 6Center for Life Sciences, Nazarbayev University, Astana, Kazakhstan Studying of the genetic diversity of indigenous populations of the Altai-Sayan Mountains creates an additional historical source for reconstruction <...>

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