CRYSTAL STRUCTURE AND INSULIN-LIKE ACTIVITY OF A VANADIUM COMPLEX DERIVED FROM /V'-(3,5-DICHLORO-2-HYDROXYBENZYLIDENE)-2-METHYLBENZOHYDRAZIDE

hydrazone ligand vanadium complex crystal structure insulin-like activity.

КВАНТОВО-ХИМИЧЕСКОЕ МОДЕЛИРОВАНИЕ ГИДРАТАЦИИ И АССОЦИАЦИИ ФЕНИЛАЛАНИНА В РАСТВОРЕ, ЭЛЕКТРОННАЯ СТРУКТУРА И ХИМИЧЕСКАЯ СВЯЗЬ В КРИСТАЛЛАХ KN3 И KSCN, ...

The X-ray analysis indicates that the V atom in the complex is in the octahedral coordination. <...> Transition metal complexes with various ligands have received much attention because they exhibit interesting biological activities. <...> The increasing interest in the coordination chemistry of vanadium arises from its well-established chemical and biological functions [ 1—5]. <...> Considering hydrazone ligands to be bioactive species [ 19 ], in the present paper, we report the synthesis, characterization, and insulin-like activity of a new vanadium complex [VOL(OMe)(MeOH)], where L is the dianionic form of the hydrazone ligand N-(3,5-dichloro-2hydroxybenzylidene)-2-methylbenzohydrazide (H2L). <...> VO(acac)2, 3,5-dichlorosalicylaldehyde, and 2-methylbenzohydrazide were purchased (Lancaster) and used as received. <...> The reaction of VO(acac)2 with N-(3,5-dichloro-2-hydroxybenzylidene)-2-methylbenzohydrazide (H2L) in methanol affords a new mononuclear vanadium (V) complex [VOL(OMe)(MeOH)]. <...> The structure of the complex is characterized by physicochemical methods and single crystal X-ray diffraction. <...> The in vitro insulinmimic activity was determined according to the literature method [ 17 ]. <...> Synthesis of the complex. 3,5-Dichloro-2-hydroxybenzaldehyde (0.19 g, 1.0 mmol) and 2-methylbenzohydrazide (0.15 g, 1.0 mmol) were dissolved and mixed in methanol (20 ml). <...> To the solution a methanol solution (20 ml) containing VO(acac)2 (0.26 g, 1.0 mmol) was added dropwise. <...> Single crystals of the complex, suitable for X-ray diffraction, were grown from the filtrate upon slow evaporation within a few days. <...> Single crystal X-ray diffraction data for the complex were collected on a Bruker Smart 1000 CCD diffractometer at 298(2) K with MoKh radiation (y = 0.71073 Е) by the scan mode. <...> The positions of the non-hydrogen atoms were located in difference Fourier maps and least-squares refinement cycles, and finally refined anisotropically. <...> The methanol hydrogen atom was located from the electron density map and refined isotropically, with O—H distance being restrained to 0.85(1) Е. <...> The hydrazone ligand was prepared by the reaction of 3,5-dichloro-2-hydroxybenzaldehyde and 2-methylbenzohydrazide in methanol. <...> The elemental analysis of the complex is in accordance with the molecular structure proposed by the X-ray analysis. <...> A perspective view of the molecular structure of the complex. <...> The molecular structure of the complex is shown in Fig. 1. <...> The V atom is in the octahedral <...>

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