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GENETICS OF HUMAN AGE RELATED DISORDERS*

Aging is an inevitable biological phenomenon. The incidence of age related disorders (ARDs) such as cardiovascular diseases, cancer, arthritis, dementia, osteoporosis, diabetes, neurodegenerative diseases increase rapidly with aging. ARDs are becoming a key social and economic trouble for the world’s elderly population (above 60 years), which is expected to reach 2 billion by 2050. Advancement in understanding of genetic associations, particularly through genome wide association studies (GWAS), has revealed a substantial contribution of genes to human aging and ARDs. In this review, we have focused on the recent understanding of the extent to which genetic predisposition may inяuence the aging process. Further analysis of the genetic association studies through pathway analysis several genes associated with multiple ARDs have been highlighted such as apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), cadherin 13 (CDH13), CDK5 regulatory subunit associated protein 1 (CDKAL-1), methylenetetrahydrofolate reductase (MTHFR), disrupted in schizophrenia 1 (DISC1), nitric oxide synthase 3 (NOS3), paraoxonase 1 (PON1), indicating that these genes could play a pivotal role in ARD causation. These genes were found to be signiёcantly enriched in Jak-STAT signalling pathway, asthma and allograft rejection. Further, interleukin-6 (IL-6), insulin (INS), vascular endothelial growth factor A (VEGFA), estrogen receptor1 (ESR1), transforming growth factor, beta 1(TGFB1) and calmodulin 1 (CALM1) were found to be highly interconnected in network analysis. We believe that extensive research on the presence of common genetic variants among various ARDs may facilitate scientists to understand the biology behind ARDs causation.

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УСПЕХИ ГЕРОНТОЛОГИИ • 2015 • Т. 28 • 2 I. Srivastava, N. Thukral, Y. Hasija, 2015 УДК 575.113:616-053 I. Srivastava, N. Thukral, Y. Hasija GENETICS OF HUMAN AGE RELATED DISORDERS* Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi-110042, India; e-mail: yashahasija@gmail.com Aging is an inevitable biological phenomenon. <...> ARDs are becoming a key social and economic trouble for the world’s elderly population (above 60 years), which is expected to reach 2 billion by 2050. <...> Advancement in understanding of genetic associations, particularly through genome wide association studies (GWAS), has revealed a substantial contribution of genes to human aging and ARDs. <...> Further analysis of the genetic association studies through pathway analysis several genes associated with multiple ARDs have been highlighted such as apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), cadherin 13 (CDH13), CDK5 regulatory subunit associated protein 1 (CDKAL-1), methylenetetrahydrofolate reductase (MTHFR), disrupted in schizophrenia 1 (DISC1), nitric oxide synthase 3 (NOS3), paraoxonase 1 (PON1), indicating that these genes could play a pivotal role in ARD causation. <...> Further, interleukin-6 (IL-6), insulin (INS), vascular endothelial growth factor A (VEGFA), estrogen receptor1 (ESR1), transforming growth factor, beta 1(TGFB1) and calmodulin 1 (CALM1) were found to be highly interconnected in network analysis. <...> We believe that extensive research on the presence of common genetic variants among various ARDs may facilitate scientists to understand the biology behind ARDs causation. <...> By 2050 the worlds elderly population (above 60 years) is expected to reach 2 billion [31]. <...> Genetics of cardiovascular disorders Besides physiological factors which are the key components of cardiac system deterioration, aging presents as a potent risk factor for cardiovascular disorders (CVD). <...> Increased uric acid level in plasma is a risk factor for CAD and hypertension [126]. <...> The involvement of a genetic variant of SLC2A9, rs7442295 in elevating blood pressure has also been reported [89]. <...> Hence high level of LPA is considered as the risk factor <...>
** - вычисляется автоматически, возможны погрешности

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