The aim of the paper is to investigate the reasons, types, and effects of cognitive dissonance with regard to intercultural communication. Cognitive dissonance can be caused by the discrepancy between the ways of categorizing and conceptualizing reality through the prism of different languages and cultures. The harmonization of mindsets and the way out of cognitive dissonance are based on the mechanisms of understanding and interaction with representatives of an alien culture in order to overcome communication breakdowns. A high level of intercultural competence requires the ability to identify the reasons for cognitive dissonance and ways to bridge intercultural differences. Interpreters, translators, and intercultural communication specialists should take the possibility of cognitive dissonance into account in their professional activities.