The deёnition of light identiёes it as the electromagnetic radiation that stimulates vision. However, we now know conclusively that photoreception in the eye leads not only to vision but also to effects on human physiology, mood and behavior, often summarized as non-visual effects of light. Research on such effects intensiёed at the beginning of this millennium. It was fueled by the revolutionary detection of a new class of photoreceptors in the human eye that detect optical radiation but do not contribute to image formation. These photoreceptors were ёrst identiёed in connection with their role in circadian regulation, particularly of the hormone melatonin, and for this reason one reads of circadian or melanopic effects. We are learning now that these photoreceptors inяuence many other processes as well. In recent years the catchphrase “Human-Centric Lighting” ( HCL) has come to describe lighting that is intended to address all of these effects. The basic evidence for the new photoreceptors, called melanopsin-containing or intrinsic photosensitive retinal ganglion cells (ipRGC), and the ёrst identiёed implications for lighting have been summarized in CIE158:2004 (which was revised to become 158:2009, including Erratum 1). CIE continued to explore this topic with two expert symposia in 2004 and 2006, with workshops at its Session meetings in 2007 and 2011, and by initiating several technical committees. Other societies also responded with events, debates, and discussion concerning how best to incorporate this knowledge into lighting practice.