РОЛЬ БЕЛКОВ СЕМЕЙСТВА BCL-2 В МИТОХОНДРИАЛЬНОЙ ДИНАМИКЕ КЛЕТОЧНОЙ ГИБЕЛИ (ОБЗОР)

апоптоз семейство Bcl-2 гибель клеток деление/слияние митохондрий.

СПЕКТРЫ КОМБИНАЦИОННОГО РАССЕЯНИЯ ПЕРХЛОРАТОВ ТЕТРАЗОЛО(ЛАТО) АММИННАТНЫХ КОМПЛЕКСОВ КОБАЛЬТА (III), Таутомерные равновесия фотоиндуцированных форм 2- и 4-(2,4-динитробензил) пиридинов, ...

Органический синтез и биотехнология УДК 576.311.347+577.23/.24 O.A. Fedorova3 D.D. Orlova1 , T.A. Grigoreva2 , V.G. Tribulovich4 MITOCHONDRIAL MORPHOGENESIS ROLE IN APOPTOSIS REGULATION (REVIEW) St. Petersburg State Technological Institute (Technical university), Moskovskiy Pr., 26, St. Petersburg, 190013, Russia e-mail: orlova.daria.d@gmail.com Mitochondria are cellular organelles responsible for cell energy balance. <...> Such organelles are in dynamic homeostasis maintained by two different processes: regulated fission (fragmentation), which leads to smaller organelle formation, and fusion, which mediates tubular and netlike mitochondrial structure formation. <...> Regulation of such processes turned out to be more complex than it supposed to be and in spite of discovered proteins which regulate fission / fusion processes, new proteins which control these processes were recently identified. <...> Recently, Bcl-2 family members have been shown to be implicated in mitochondrial netlike structure maintenance in addition to their key role in regulation of apoptosis. <...> In this review we discuss mitochondrial fission / fusion mechanisms regulation and summarize available data on the role of Bcl-2 family members in the mitochondrial fission / fusion dynamics regulation. <...> Mitochondria act as key regulators of apoptosis in tablished many years ago, however, the recent studies of mitochondrial dynamics have shown their role in a number of other physiological processes taking place at the cellular level in health and disease. <...> Mitochondria are dynamic organelles exposed to regulated fission, fusion, branching, intracellular localization changes, compositional changes including mitochondrial genome, reshaping, and quantity adjustment. <...> Mitochondrial morphology and their number depend on the balance between fusion and fission rates. <...> Shift towards the fusion process enables the formation of extended interconnected mitochondrial networks, whereas shift towards fission provoke production of a large amount of morphologically and functionally different small spherical organelles. <...> These processes are controlled by proteins of the mitochondrial dynamics machinery and play vital role in normal cell physiology. 1 mammalian cells. <...> Mitochondria involvement in apoptosis is regulated by Bcl-2 (B-cell lymphoma 2) protein. <...> This protein retains cells from death and under certain conditions plays the role of oncogene. <...> Besides, mitochondria contribute to cell <...>

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