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FEASIBILITY STUDY — VITAMIN D LOADING DETERMINATION BY FTIR-ATR

Purpose: The aim of the present study was to develop a simple and accurate way to measure vitamin D levels. Vitamin D nowadays is measured by a variety of methods which their common drawbacks are expensive equipment and the need for high trained technical staff. In this research we measured vitamin D levels by means of Fourier transform infra red method in conjugation with the evanescent wave spectroscopy technique, in order to develop a simpler vitamin D measurement method. Methods: Blood samples were collected from patients with vitamin D deficiency at five intervals before and up to 16 days after they took a dose of 200,000 IU vitamin D3. Samples were measured by the conventional bio-chemical method and by the evanescent wave spectroscopy means. Results: Correlation was found between the vitamin D levels measured by the traditional method and by the evanescent wave spectroscopy technique. The absorption lines occurred prominently in the IR spectral regions of the Amide I (≈1650 cm−1),Amide II (≈1530 cm−1) and the (≈3400 cm−1) absorption band which is attributed to the hydroxyl group indicated by the O-H stretch. In addition, the examination of the blood samples using the evanescent wave spectroscopy with clustering techniques facilitated the discrimination between vitamin D deficiency and normal vitamin D levels. Practical relevance: This study demonstrates the potential of using the Fourier transform infra red method in conjugation with the evanescent wave spectroscopy techniquecoupled with multivariate analysis as a nonexpensive, rapid and accurate alternative to the routine methodologies.

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УПРАВЛЕНИЕ В МЕДИЦИНЕ И БИОЛОГИИ UDC 543.2 doi:10.15217/issn1684-8853.2015.3.107 FEASIBILITY STUDY — VITAMIN D LOADING DETERMINATION BY FTIR-ATR E. Simanaa, B.Sc., Electrical Engineering, eran.simana@gmail.com R. Simiana, B.Sc., Electrical Engineering, ronensimian@gmail.com S. Portnoyb, PhD, Biomedical Engineering, portnoys@tauex.tau.ac.il A. Jaffec, M.D, PhD, Endocrinologist, jaffe@hy.health.gov.il B. Z. Dekela, PhD, Electrical Engineering, benziond@ruppin.ac.il aRuppin Academic Center, Emek-Hefer, 40250, Israel bOccupation Therapy Department, Tel-Aviv University, Tel-Aviv, Israel cEndocrinology and Diabetes Unit, Hillel Yaffe Medical Center, Hadera, Israel 16 days after they took a dose of 200,000 IU vitamin D3. <...> Samples were measured by the conventional bio-chemical method and by the evanescent wave spectroscopy means. <...> Results: Correlation was found between the vitamin D levels measured by the traditional method and by the evanescent wave spectroscopy technique. <...> The absorption lines occurred prominently in the IR spectral regions of the Amide I (1650 cm1),Amide II (1530 cm1) and the (3400 cm1) absorption band which is attributed to the hydroxyl group indicated by the O-H stretch. <...> In addition, the examination of the blood samples using the evanescent wave spectroscopy with clustering techniques facilitated the discrimination between vitamin D deficiency and normal vitamin D levels. <...> Practical relevance: This study demonstrates the potential of using the Fourier transform infra red method in conjugation with the evanescent wave spectroscopy techniquecoupled with multivariate analysis as a nonexpensive, rapid and accurate alternative to the routine methodologies. <...> Keywords — FTIR-ATR Spectroscopy, Mid Infrared, Vitamin D. Introduction It has been well-known for decades that vitamin D is activated in the skin by ultraviolet B radiation and that its main activities are calcium balanceby affectingcalciumabsorption, secretion, bone metabolism and control of PTH. <...> Hence, there is great need for a fast, low-cost, safe, simple and accurate method for measuring vitamin D or at least one that will indicate vitamin D status as normal, low level or severely deficient. <...> In recent decades, fourier transform infrared (FTIR) spectroscopy with or without attenuated total reflection (ATR) accessory, is a field <...>
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