Physical status of children born in 1996 (longitudinal auxological study of children from Vilnius city, 1996-2013)
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Section GROWTH and DEVELOPMENT
LONGITUDINAL COHORT STUDY OF GROWTH, DEVELOPMENT, PUBERTY
AND REPRODUCTIVE HEALTH IN RUSSIAN BOYS
Sergeyev Oleg 1,2
Revich Boris6
, Lam Thuy3
, Dikov Yury1
, Williams Paige L.4
, Sergeyeva Lyubov1
1Chapaevsk Medical Association, Chapaevsk, Russia
2Vavilov Institute of General Genetics, Moscow, Russia
3Department of Environmental Health, Harvard School of Public Health, Boston, USA
4Departments of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, USA
5Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, USA
6Institute of Forecasting, Russian Academy of Sciences, Moscow, Russia
7
Pediatric Endocrine Division, Departments of Pediatrics and Cell and Developmental Biology, University of
Massachusetts Medical School, Worcester, USA
Introduction. <...> There are few longitudinal male cohort studies with serial assessments of growth and puberty. <...> We assembled a multi-disciplinary team of U.S. and Russian researchers to design
and conduct a longitudinal boys’ cohort study of male growth, development, puberty and reproductive health in
Chapaevsk, Russia. <...> At annual study visits scheduled at each subject’s birth month, the same study physician
(O.S.) assesses pubertal staging and one nurse (L.S.) measures anthropometric variables. <...> Pubertal assessments
are based on a 1–5 scale for genitalia and pubic hair staging by visual inspection, testicular volume
is measured using orchidometers, and penile length is measured with a ruler. <...> In
2003–2005, 516 prepubertal boys were recruited at ages 8–9 years (86% of all eligible Chapaevsk boys) to
be followed annually for at least 10 years. <...> The participation rate has remained high with over 75% followed for
6 years and 64% at 9 years of follow-up with 4319 visits as of February 2014. <...> Longitudinal curves for
selected anthropometric and pubertal measures will be constructed. 113 semen samples were collected at
18-19 years old and evaluated for semen quality, including sperm concentration and motility. <...> To our knowledge, this longitudinal male cohort is the fi rst to have serial assessments of growth and puberty
performed by the same physician and nurse followed for over ten years, from prepuberty <...>
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