Influence of genetic polymorphism +1663A/G TNFR2 on the development of chronic true eczema

genetic polymorphism +1663A/G TNFR2 генетический полиморфизм chronic true eczema eczema экзема dermatology immunological disorders иммунологические нарушения DNA ДНК дезоксирибонуклеиновая кислота alleles аллели genes гены

Genetic traces of the Turkic influence in Armenians and neighboring populations, Deep-rooting African influence in Southwestern Europe, ...

118 Section MOLECULAR ANTHROPOLOGY – NEW ADVANCES and the Central Tuvinians, are characterized by the maximum range of haplogroups. <...> More than a quarter of the Y-gene pool belonged to North Eurasian haplogroups Q-M242, the fi fth part of the gene pool consists of West Eurasian haplogroup R1a1a-M198. <...> The genetic structure of the studied populations of Tuvinians and Todzhintsy was computed by the analysis of molecular variance (AMOVA), with Fst=0.085. <...> The cluster analysis of the populations of Southern Siberia on the matrix of genetic distances (average d=0.4) has shown that all Tuvinians and Todzhintsy formed a united cluster together with Khakas-Sagaytsy. <...> Our results indicate the general background in the origin of the populations of Tuvinians and the preservation of an ancient “Siberian” layer (N1b-P-43, N1c1a-M178, Q-M242) in the gene pool of Todzhintsy in the conditions of geographical isolation in mountain and taiga areas. <...> It can be emphasized that the conditions formed a refugium, where the gene pool kept traces of the ancient population of Southern Siberia. <...> INFLUENCE OF GENETIC POLYMORPHISM +1663A/G TNFR2 ON THE DEVELOPMENT OF CHRONIC TRUE ECZEMA Denisova Ya., Chournosov M., Krikun E. Belgorod National Research University, Belgorod, Russia Among the cases of chronic dermatosis, eczema makes 30 to 40%. <...> The rise of sickness rate, the chronicity of the disease process, the frequent recurrence of its course, insuffi cient effect of the treatment methods make chronic eczema the most pressing problem in the modern dermatology. <...> At present the leading pathogenic link of eczema development is considered to be a marked immunological disorders. <...> The extraction of genome DNA from peripheral blood is made with the method of phenol-chlorophorm extraction. <...> PCR was made on the amplifi er IQ 5 (Bio-Rad) in the real time mode of operation with the use of DNA polymerases Thermus aquaticus and oligonucleotide primers and probes. <...> Genotyping of DNA markers is made with the method of allele discrimination on the base of Tag Man probes. <...> This allows us to come to a conclusion that the polymorphism +1663A/G TNFR2 is not associated with the development of chronic true eczema. <...> Key words: eczema, genetic polymorphism, natives of the Central Chernozem region of Russia Contact information: Krikun Evgeniy, e-mail: krikun@bsu.edu.ru Vestnik Moskovskogo Universiteta. <...> Influence of genetic polymorphism +1663A/G TNFR2 on the development of chronic true <...>

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