Бактериофаги в терапии и профилактике острых кишечных инфекций у детей

бактериофаги дети фаготерапия фагопрофилактика острые кишечные инфекции

Прогнозирование развития анемии у новорожденных с перинатальными гипоксическими поражениями ЦНС в условиях микроэлементоза, Взаимосвязь антибиотикотерапии и манифестации бронхообструктивного синдрома в раннем детском возрасте, ...

Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Moscow, Russian Federation; 2N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation The review presents data about the history and present-day of using bacteriophage preparations in treatment and prevention of various infectious diseases in pediatrics. <...> It sums up the results of numerous Russian studies of the efficacy and safety of the employed phages in treatment of acute intestinal infections and decompensated forms of dysbacteriosis in children from birth. <...> The development of new ideas in molecular biology, ecological interrelations between bacteriophages and their hosts, along with the growing concern about antibiotic-resistant strains of microorganisms necessitate a more thorough research of the possibilities of using phages in clinical practice. <...> In this context, phages have been used to prevent and/or treat infectious diseases of bacterial etiology (including in newborns and young children) for almost a century. <...> Given the ability of lytic phages to kill bacteria that cannot be killed by commonly available antibiotics, it seems prudent that this approach is rigorously evaluated in carefully designed clinical trials. <...> Keywords: bacteriophage, children, phage therapy, phage prophylaxis, acute intestinal infections Бактериофаги в терапии и профилактике острых кишечных инфекций у детей А.В.Алёшкин1 , М.В.Зейгарник2 Российская Федерация; 2 , С.С.Бочкарева1 1Московский НИИ эпидемиологии и микробиологии им. <...> Развитие новых представлений о молекулярной биологии, об экологических взаимоотношениях бактериофагов и их хозяев, а также все более широкое распространение антибиотикорезистентных штаммов микроорганизмов диктуют актуальность более пристального изучения возможности применения фагов в клинической практике. <...> Ключевые слова: бактериофаги, дети, фаготерапия, фагопрофилактика, острые кишечные инфекции B acterial viruses were discovered by Frederick Twort in 1915, but the era of bacteriophages began after papers on the subject were published by Felix d’Herelle, who was the first to demonstrate the presence of phages in normal microflora of humans and animals 95 years ago [1, 2]. <...> For the first time bacteriophages were applied in pediatrics against dysentery in 1919. <...> A phage preparation was pre-tested perorally by d’Herelle, Victor-Henri Hutinel (the hospital’s Chief) and several interns of the children’s hospital “Hфpital <...>

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