Worldwide, the mineral fertilizers, because of their multiple negative effects, become less popular. Therefore, more producers prefer to use biofertilizer and biological preparations for obtaining high crop yield with good quality. Fertilizers fill the soil with additional material, while biologicals contribute to effective mobilization of soil organic matter and biota. At All-Russian Research Institute of Reclaimed Lands (VNIIMZ) the КMN biofertilizer (multi-purpose compost) has been developed. Advantage of the КMN as a base fertilizer lies in its high nutritional value, physiological, ecological and biogenic properties. Also, a novel biological product, the LPB, have been developed. It is characterized by the presence of physiologically relevant amounts of growth factors and energy sources in a combination favorable to the plant. The LPB composition allows to maintain soil fertility and crop productivity. In the present study, we evaluated the effectiveness of the KMN and LPB on the potato (Solanum tubetosum L.) variety Zhukovsky and spring wheat (Triticum aestivum L.) variety Irgina.