STRUCTURE AND BIOLOGICAL EVALUATION OF (E)-5-BROMO-2-METHOXY4-((PHENYLIMINO)METHYL)PHENOL DERIVATIVES AS ANTIBACTERIAL AGENTS
Three (E)-5-bromo-2-methoxy-4-((phenylimino)methyl)phenol derivatives (1—3) are synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The antibacterial activities of compounds 1—3 against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus are evaluated by the MTT method.
Авторы
Тэги
Тематические рубрики
Предметные рубрики
В этом же номере:
Резюме по документу**
2015. 56, 2
UDC 541.6:548.737
STRUCTURE AND BIOLOGICAL EVALUATION OF (E)-5-BROMO-2-METHOXY4-((PHENYLIMINO)METHYL)PHENOL
DERIVATIVES AS ANTIBACTERIAL AGENTS
W. Zhou, J. Ma, R.-J. Yuan, X. Han, H.-G. Liu, H.-L. Zhu
School of Life Sciences, Shandong University of Technology, ZiBo 255049, P. R. China
Email: hailiang_zhu@163.com (H.-L. Zhu)
Received July, 20, 2013
Revised — November, 4, 2013
Three (E)-5-bromo-2-methoxy-4-((phenylimino)methyl)phenol derivatives (1—3) are synthesized
and characterized by elemental analysis and single-crystal X-ray diffraction. <...> The antibacterial
activities of compounds 1—3 against Escherichia coli, Pseudomonas aeruginosa, Bacillus
subtilis, and Staphylococcus aureus are evaluated by the MTT method. <...> INTRODUCTION
Although several classes of antibacterial agents are presently available, resistance to these drugs
constantly emerges in most of the pathogenic bacteria. <...> In order to prevent this serious medical problem,
the elaboration of new types of antibacterial agents is a very important task [ 1 ]. <...> Apart of its flavor
qualities, vanillin exhibits the antimicrobial potential and has been used as a natural food preservative
[ 2 ]. <...> Schiff bases, named after Hugo Schiff [ 3 ], have also been shown to exhibit a broad range of
biological activities, including antifungal, antibacterial, anti-malarial, antiproliferative, anti-inflammatory,
antiviral, and antipyretic properties [ 4—12]. <...> The molecular hybridization approach is one of the most valuable structural modification tools
useful for the discovery of ligands and prototypes presenting either optimized affinity for one bioreceptor
or the ability to modulate more than one bioreceptor associated with the target disease [ 13 ]. <...> Hence, the impressive results of vanillin derivatives and various phenylamine
fueled our interest in combining two scaffolds and exploring their possibilities as antibacterial
agents. <...> The crystal structures of compounds (1—3) were determined. <...> General synthesis method of (E)-5-bromo-2-methoxy-4-((phenylimino)methyl)phenol derivatives
(1—3). <...> The organic layer was filtered, and concentrated under reduced pressure to give the pure compound a. <...> After cooling in the air, the resultant solid was filtered, washed with water, and dried to give the compound c. The equivocal compound c and substituted aromatic amine <...>
** - вычисляется автоматически, возможны погрешности
Похожие документы: